Study of calcium profile in neuronal cells with respect to temperature and influx due to potential activity

Calcium is a critically important second messenger in the nervous system. It enters through voltage-gated Ca2+ channels and regulates release of synaptic transmitter. This mechanism monitored by calcium diffusion, buffering influx into cytoplasm. The study dynamics interesting because concentration shows highly complex spatial-temporal behavior. There are many controls on cytoplasmic concentration. First, it heavily buffered (i.e., bound) large proteins control that variable diffusion coefficient. coefficient directly proportional to temperature inversely viscosity. In this paper, one-dimensional steady-state case with boundary conditions has been studied understand distribution neuronal cells incorporating calcium, point source, excess buffer approximation (EBA), an due current. Moreover, dependency based studied. finite element method (FEM) employed obtain solutions.